Prof. dr hab. Joanna Cichy
room: C220 (2.1.24), phone: +48 12 664 61 27, e-mail: joanna.cichy@uj.edu.pl

Dr hab. Małgorzata Bzowska
room: C222 (2.1.26), phone: +48 12 664 61 58, e-mail: malgorzata.bzowska@uj.edu.pl

Dr Krzysztof Guzik
room: C223 (2.1.27), phone: +48 12 664 61 37, e-mail: krzysztof.guzik@uj.edu.pl

Dr Mateusz Kwitniewski
room: C220 (2.1.24), phone: +48 12 664 61 35, e-mail: mateusz.kwitniewski@uj.edu.pl

Dr Ewa Oleszycka
room: C221 (2.1.25), phone: +48 12 664 62 01, e-mail: ewa.oleszycka@uj.du.pl

Dr Joanna Skrzeczyńska–Moncznik
room: C222 (2.1.26), phone: +48 48 12 664 61 58, e-mail: j.skrzeczynska-moncznik@uj.edu.pl

Michelle Elena Camacho Araque, room: C223 (2.1.28), phone: +48 12 664 61 61
Angelika Mazur, room: C223 (2.1.28), phone: +48 12 664 61 61
Natalia Pocałuń, room: C223 (2.1.28), phone: +48 12 664 61 61
Ivan Sinkevich, room: C224 (2.1.28), phone: +48 12 664 61 61
Mariia Tyshchenko, room: C224 (2.1.28), phone: +48 12 664 61 61
 

• The role of proteinases and their inhibitors in regulation of immune responses
• Mechanisms underlying neutropenia
• Pathogenesis of autoimmune and allergic diseases, including skin disease psoriasis
• The role of chemoattractant protein-chemerin in immune and metabolic responses
• Diagnosis and mechanism of drug hypersensitivity reactions
• Mechanisms of recognition of dying cells by professional phagocytes
• The role of 27kDa Heat Shock Protein (HSP27) in the formation of damage-associated molecular patterns (DAMPs)
• The role of cell surface 90kDa Heat Shock Protein (HSP90) in the recognition of molecular patterns
• The influence of low-density oxidised lipoproteins (oxLDL) on the recognition of molecular patterns by professional phagocytes

• Flow cytometry and cell sorting (LSRII, 16 colors; automatic magnetic cell sorter)
• Fluorescence microscopy (fully-motorized NIKON Eclipse microscope)
• Gene expression analysis (qPCR)
• Protein analysis (ELISA, Western Blot, Multiplex)
• Metabolic analysis (Seahorse XFp)
• Production of mutant proteins
• Analysis of DNA metylation
• Isolation and tissue culture of primary cells (keratinocytes, adipocytes, hepatocytes)
• 3D cultures of keratinocytes
• Experimental mouse models (psoriasis model, SLPI, Tig2 and CMKLR1 KO mice)

1. Joanna Cichy: Role of neutrophil serine proteases in chronic inflammatory skin diseases associated with Regnase-1 malfunction. (2023–2027).OPUS 23, National Science Centre (NCN).
2. Ewa Oleszycka:  Deciphering the molecular mechanism of inflammation orchestrated by keratinocytes during Staphylococcus aureus infection in the skin, (2023–2025), HORIZON-WIDERA-2022-TALENTS-02
3. Mieszko Wilk: Regulation of SLPI-IL-17 signaling pathway during respiratory infections and vaccination. (2022–2024) POLONEZ BIS 1, National Science Centre (NCN) – Marie Skłodowska-Curie COFUND.
4. Ewa Oleszycka: Defining the interplay between SLPI and the IL-1 family cytokines in the immune response. (2021–2024) SONATA 16, National Science Centre (NCN).
5. Joanna Cichy: The role of epidermal protein Regnase-1 in chronic itch-associated diseases. (2020–2024).OPUS 18, National Science Centre (NCN).

1. Skrzeczynska-Moncznik J, Zabieglo K, Osiecka O, Morytko A, Brzoza P, Drozdz L, Kapinska-Mrowiecka M, Korkmaz B, Pastuszczak M, Kosalka-Wegiel J, Musial J, Cichy J. Differences in Staining for Neutrophil Elastase and its Controlling Inhibitor SLPI Reveal Heterogeneity among Neutrophils in Psoriasis. J Invest Dermatol. 2020 Jul;140(7):1371-1378.
2. Cassetta L, Bruderek K, Skrzeczynska-Moncznik J, Osiecka O, Hu X, Rundgren IM, Lin A, Santegoets K, Horzum U, Godinho-Santos A, Zelinskyy G, Garcia-Tellez T, Bjelica S, Taciak B, Kittang AO, Höing B, Lang S, Dixon M, Müller V, Utikal JS, Karakoç D, Yilmaz KB, Górka E, Bodnar L, Anastasiou OE, Bourgeois C, Badura R, Kapinska-Mrowiecka M, Gotic M, Ter Laan M, Kers-Rebel E, Król M, Santibañez JF, Müller-Trutwin M, Dittmer U, de Sousa AE, Esendağlı G, Adema G, Loré K, Ersvær E, Umansky V, Pollard JW, Cichy J, Brandau S. Differential expansion of circulating human MDSC subsets in patients with cancer, infection and inflammation. J Immunother Cancer. 2020 Sep;8(2):e001223
3. Kwiecien K, Brzoza P, Bak M, Majewski P, Skulimowska I, Bednarczyk K, Cichy J, Kwitniewski M. The methylation status of the chemerin promoter region located from - 252 to + 258 bp regulates constitutive but not acute-phase cytokine-inducible chemerin expression levels. Sci Rep. 2020 Aug 13;10(1):13702.
4. Godlewska U, Bilska B, Zegar A, Brzoza P, Borek A, Murzyn K, Bochenska O, Morytko A, Kuleta P, Kozik A, Pyza E, Osyczka A, Zabel BA, Cichy J. The antimicrobial activity of chemerin-derived peptide p4 requires oxidative conditions. J Biol Chem. 2019 Jan 25; 294(4):1267-1278. 
5. Kwiecien K, Zegar A, Jung J, Brzoza P, Kwitniewski M, Godlewska U, Grygier B, Kwiecinska P, Morytko A, Cichy J. Architecture of antimicrobial skin defense. Cytokine Growth Factor Rev. 2019 Aug 15. S1359-6101(19)30074-7.
6. Godlewska U, Brzoza P, Sroka A, Majewski P, Jentsch H, Eckert M, Eick S, Potempa J, Zabel BA, Cichy J. Antimicrobial and Attractant Roles for Chemerin in the Oral Cavity during Inflammatory Gum Disease. Front Immunol. 2017 Mar 29;8:353. eCollection 2017
7. Bzowska M., Nogieć A., Bania K., Zygmunt M., Zarębski M., Dobrucki J., Guzik K. Involvement of cell surface 90 kDa heat shock protein (HSP90) in pattern recognition by human monocyte-derived macrophages. J Leukoc Biol. 2017 Sep;102(3):763-774,
8. Skrzeczyńska-Moncznik J., Bzowska M., Nogieć A., Sroka A., Zarębski M., Vallières L., Guzik K. Rapid externalization of 27-kDa heat shock protein (HSP27) and atypical cell death in neutrophils treated with the sphingolipid analog drug FTY720. J Leukoc Biol. 2015;98(4):591-9.
9. Zabieglo K., Majewski P., Majchrzak-Gorecka M., Wlodarczyk A., Grygier B., Zegar A., Kapinska-Mrowiecka M., Naskalska A., Pyrc K., Dubin A., Wahl S.M., Cichy J. The inhibitory effect of secretory leukocyte protease inhibitor (SLPI) on formation of neutrophil extracellular traps. J Leukoc Biol. 2015;98(1):99-106.
10. Marczynska J., Ozga A., Wlodarczyk A., Majchrzak-Gorecka M., Kulig P., Banas M., Michalczyk-Wetula D., Majewski P., Hutloff A., Schwarz J., Chalaris A., Scheller J., Rose-John S., Cichy J. The role of metalloproteinase ADAM17 in regulating ICOS ligand-mediated humoral immune responses. J Immunol. 2014;193(6):2753-63.

• The role of proteinases and their inhibitors in regulation of immune responses
• Pathogenesis of autoimmune diseases, including skin disease psoriasis
• Mechanisms underlying formation and inhibition of neutrophil extracellular traps (NETs)
• The role of chemoattractant protein-chemerin in immune and metabolic response
• Mas-related G protein-coupled receptor-X2 (MRGPRX2) in drug hypersensitivity reactions