Skip to main content

Web Content Display Web Content Display

Web Content Display Web Content Display

Department of Immunology

WWW

www.immunologia.wbbib.uj.edu.pl

Head

Prof. dr hab. Joanna Cichy
room: C220 (2.1.24), phone: +48 12 664 61 27, e-mail: joanna.cichy@uj.edu.pl

Staff

Dr. Katarzyna Bulek
room: C221 (2.1.25), phone: +48 12 664 62 01, e-mail: katarzyna.bulek@uj.edu.pl

Dr. Krzysztof Guzik
room: C223 (2.1.27), phone: +48 12 664 61 37, e-mail: krzysztof.guzik@uj.edu.pl

Dr. Mateusz Kwitniewski
room: C220 (2.1.24), phone: +48 12 664 61 35, e-mail: mateusz.kwitniewski@uj.edu.pl

Dr. Joanna Skrzeczyńska–Moncznik
room: C222 (2.1.26), phone: +48 48 12 664 61 58, e-mail: j.skrzeczynska-moncznik@uj.edu.pl

Dr. Małgorzata Bzowska
room: C222 (2.1.26), phone: +48 12 664 61 58, e-mail: malgorzata.bzowska@uj.edu.pl

Dr. Małgorzata Bodaszewska-Lubaś
room: C221 (2.1.25), phone: +48 12 664 62 01, e-mail: malgorzata.bodaszewska@uj.edu.pl

Dr. Beata Grygier
room: C220 (2.1.24), phone: +48 12 664 61 35, e-mail: beata.grygier@uj.edu.pl

Dr. Dorota Kozłowska-Chmielewska
room:  C221 (2.1.25), phone: +48 12 664 62 01, e-mail: dorota.kozlowska@uj.edu.pl

Dr. Patrycja Kwiecińska
room: C220 (2.1.24), phone: +48 12 664 61 35, e-mail: patrycja.kwiecinska@uj.edu.pl

Dr. Paweł Majewski
room: C220 (2.1.24), phone: +4812 664 61 35, e-mail: pawel.majewski@uj.edu.pl

Dr. Katarzyna Szmyd
room: C219 (2.1.23), phone: +48 12 664 61 26, e-mail: katarzyna.szmyd@uj.edu.pl

Mgr Kamila Kwiecień
room: C219, (2.1.23), phone: +48 12 664 61 26, e-mail: kamila.kwiecien@uj.edu.pl

Mgr Alicja Uchańska
room: C223, (2.1.28), phone: +48 12 664 61 61, e-mail: alicja.stec@uj.edu.pl

PhD students

Piotr Brzoza, room: C223 (2.1.28), phone: +48 12 664 61 61
Kamila Kwiecień, room: C223 (2.1.28), phone: +48 12 664 61 61
Urszula Godlewska, room: C223 (2.1.28), phone: +48 12 664 61 61
Monika Majchrzak-Górecka, room: C221 (2.1.25),phone: +48 12 664 62 01
Agnieszka Morytko, room: C223 (2.1.28), phone: +48 12 664 61 61
Oktawia Osiecka, room: C223 (2.1.28), phone: +48 12 664 61 61
Aneta Zegar, room: C221 (2.1.25), phone: +48 12 664 62 01

Research topics

  • The role of proteinases and their inhibitors in regulation of immune responses
  • Pathogenesis of autoimmune and allergic diseases, including skin disease psoriasis
  • Mechanisms underlying formation and inhibition of neutrophil extracellular traps (NETs)
  • The role of chemoattractant protein-chemerin in immune and metabolic responses
  • Mechanisms of recognition of dying cells by professional phagocytes
  • The role of 27kDa Heat Shock Protein (HSP27) in the formation of damage-associated molecular patterns (DAMPs)
  • The role of cell surface 90kDa Heat Shock Protein (HSP90) in the recognition of molecular patterns
  • The influence of low-density oxidised lipoproteins (oxLDL) on the recognition of molecular patterns by professional phagocytes

Methods and specialized equipment

  • Flow cytometry and cell sorting (LSRII, 16 colors; automatic magnetic cell sorter)
  • Fluorescence microscopy (fully-motorized NIKON Eclipse microscope)
  • Gene expression analysis (qPCR)
  • Protein analysis (ELISA, Western Blot, Multiplex)
  • Metabolic analysis (Seahorse XFp)
  • Production of mutant proteins
  • Analysis of DNA metylation
  • Isolation and tissue culture of primary cells (keratinocytes, adipocytes, hepatocytes)
  • 3D cultures of keratinocytes
  • Experimental mouse models (psoriasis model, SLPI, Tig2 and CMKLR1 KO mice)

Current projects

  1. Joanna Cichy: SLPI-dependent cutaneous antimicrobial and antiviral immunity. (2018-2021).OPUS 13, National Science Centre (NCN).
  2. Patrycja Kwiecińska: The role of acyl-CoA:diacylglycerol acyltransferase 1 in proinflammatory neutrophil response in psoriasis. (2018-2021) SONATA 13, National Science Centre (NCN)
  3. Beata Grygier: SLPI – novel regulator involved in the neuro-immune interplay in psoriasis (2017-2020). SONATA 12, National Science Centre (NCN).
  4. Małgorzata Bodaszewska-Lubaś: Evaluation of the binding ability of SIGIRRΔeX8 protein to DNA aptamer (2019-2020). MINIATURA2, National Science Centre (NCN)
  5. Katarzyna Bulek: Mechanism of epigenetic-driven inactivation of tumor suppressor SIGIRR (2016-2019). OPUS 10, National Science Centre (NCN).
  6. Joanna Cichy: Role of antibacterial chemerin in skin pathophysiology. (2014-2019). SYMFONIA 2, National Science Centre (NCN).

Selected publications

  1. Godlewska U, Bilska B, Zegar A, Brzoza P, Borek A, Murzyn K, Bochenska O, Morytko A, Kuleta P, Kozik A, Pyza E, Osyczka A, Zabel BA, Cichy J. The antimicrobial activity of chemerin-derived peptide p4 requires oxidative conditions. J Biol Chem2019 Jan 25; 294(4):1267-1278. 
  2. Kwiecien K, Zegar A, Jung J, Brzoza P, Kwitniewski M, Godlewska U, Grygier B, Kwiecinska P, Morytko A, Cichy J. Architecture of antimicrobial skin defense. Cytokine Growth Factor Rev2019 Aug 15. S1359-6101(19)30074-7.
  3. Godlewska U, Brzoza P, Sroka A, Majewski P, Jentsch H, Eckert M, Eick S, Potempa J, Zabel BA, Cichy J. Antimicrobial and Attractant Roles for Chemerin in the Oral Cavity during Inflammatory Gum Disease. Front Immunol2017 Mar 29;8:353. eCollection 2017
  4. Bzowska M., Nogieć A., Bania K., Zygmunt M., Zarębski M., Dobrucki J., Guzik K. Involvement of cell surface 90 kDa heat shock protein (HSP90) in pattern recognition by human monocyte-derived macrophages.  J Leukoc Biol2017 Sep;102(3):763-774,
  5. Skrzeczyńska-Moncznik J., Bzowska M., Nogieć A., Sroka A., Zarębski M., Vallières L., Guzik K. Rapid externalization of 27-kDa heat shock protein (HSP27) and atypical cell death in neutrophils treated with the sphingolipid analog drug FTY720. J Leukoc Biol2015;98(4):591-9.
  6. Zabieglo K., Majewski P., Majchrzak-Gorecka M., Wlodarczyk A., Grygier B., Zegar A., Kapinska-Mrowiecka M., Naskalska A., Pyrc K., Dubin A., Wahl S.M., Cichy J. The inhibitory effect of secretory leukocyte protease inhibitor (SLPI) on formation of neutrophil extracellular traps. J Leukoc Biol2015;98(1):99-106.
  7. Marczynska J., Ozga A., Wlodarczyk A., Majchrzak-Gorecka M., Kulig P., Banas M., Michalczyk-Wetula D., Majewski P., Hutloff A., Schwarz J., Chalaris A., Scheller J., Rose-John S., Cichy J. The role of metalloproteinase ADAM17 in regulating ICOS ligand-mediated humoral immune responses. J Immunol. 2014;193(6):2753-63.
  8. Skrzeczynska-Moncznik J., Wlodarczyk A., Zabieglo K., Kapinska-Mrowiecka M., Marewicz E., Dubin A., Potempa J., Cichy J. Secretory leukocyte proteinase inhibitor-competent DNA deposits are potent stimulators of plasmacytoid dendritic cells: implication for psoriasis. J Immunol. 2012;189(4):1611-7.
  9. Kulig P., Kantyka T., Zabel B.A., Banas M., Chyra A., Stefanska A., Tu H., Allen S.J., Handel T.M., Kozik A., Potempa J., Butcher E.C., Cichy J. Regulation of chemerin chemoattractant and antibacterial activity by human cysteine cathepsins. J Immunol2011;187(3):1403-10.
  10. Kulig, P. Zabel, B. A., Dubin, G., Allen, S. J., Ohyama, T., Potempa, J., Handel, T. M., Butcher, E. C., and Cichy, J. Staphylococcus aureus-derived staphopain B, a potent cysteine protease activator of plasma chemerin. J. Immunol2007;178:3713-20.

Batchelor/master thesis topics

  • The role of proteinases and their inhibitors in regulation of immune responses
  • Pathogenesis of autoimmune diseases, including skin disease psoriasis
  • Mechanisms underlying formation and inhibition of neutrophil extracellular traps (NETs)
  • The role of chemoattractant protein-chemerin in immune and metabolic response

Requirements for candidates

  • Interest in experimental immunology
  • Basic knowledge in immunology, molecular biology and cell biology 
  • Proficiency in spoken and written English