Postdoctoral position avaiable at the Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University in Kraków, Poland. The application deadline is February 17, 2022.
We are seeking a highly motivated Postdoctoral Researcher to join the project entitled “Mechanistic links between psoriasis and cardiovascular complications: investigation on inflammation induced alterations in induced pluripotent stem cells-derived endothelial cells, cardiomyocytes and cardiac organoids” led by Dr. Monika Biniecka. The project is supported by NCN funding (Sonata Bis, project no. 2018/30/E/NZ5/0048).
About the project
The overall goal of this proposal is to determine the mechanism by which cutaneous inflammation promotes cardiovascular disease (CVD) in psoriasis (Ps). This project proposes a truly translational, benchto-bedside approach building on the strength of the human and murine Ps model and a recent progress in generating human induced pluripotent stem cells (iPSC). By reprogramming skin fibroblast cells and peripheral blood mononuclear cells (PBMCs) into iPSC and their differentiation, we will establish a unique source of personalized functional iPSC-derived endothelial cells (EC) and iPSC-derived cardiomyocytes (CM). To capture EC-CM interactions in vitro, we will design a complex 3D cardiac microtissues (MT-CMEC) that may truly represent in vivo cardiac environment.
About your position and the project
You will be responsible for the generation and characterization of the 3D cardiac microtissues (MT-CMEC) as well us animal experiments. Financial support for this position is available for up to three years (120 000 PLN/year gross gross). Start date is negotiable, but the position is immediately available. The requirements
- PhD degree* awarded in life science field awarded on or after 2016**;
- Scientific achievements documented by publications in international journals;
- Fluent knowledge of cell culture methods;
- Experience in other techniques of molecular biology;
- Experience in animal research;
- Good command of spoken and written English.
How to apply?
Interested candidates should send: a cover letter discussing their research experience, a detailed CV, and the contacts details for two referees as a single pdf file to: monika.biniecka@uj.edu.pl
Informal inquiries and questions are welcome.
Application deadline
17.02.2023
*PhD degree awarded from a university other than Jagiellonian University.
**Exceptions possible as per NCN guidelines in the case of documented child-care etc.
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