Stipends for MSc student in the Department of Microbiology available from 1st March 2020. The closing date for applications is the 19th January 2020.
Position in the project: Student - MSc
Scientific discipline: Microbiology, immunology
Job type: Stipend
Number of job offers: 1
Remuneration/stipend amount/month: 1500 PLN/month (non-taxable)
Position starts on: 1.03.2020
Maximum period of contract/stipend agreement: 12 months
Institution: Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow
Project leader: dr Aleksander Grabiec
Project title: “Epigenetics of periodontitis: DNA methylation in disease development and as a potential therapeutic target.”
Project is carried out within the First Team programme of the Foundation for Polish Science
Project description:
The aim of this project is to analyze pathological changes in DNA methylation in gingival cells from patients with periodontitis, identify the influence of Porphyromonas gingialis on DNA methylation in these cells and characterize its biological consequences. Studies performed within this project will not only improve our understanding of this disease, but can also facilitate identification of new therapeutic targets, constituting a foundation for testing new drug classes in the treatment of periodontal disease in the future.
The aim of this project is to analyze pathological changes in DNA methylation in gingival cells from patients with periodontitis, identify the influence of Porphyromonas gingialis on DNA methylation in these cells and characterize its biological consequences. Studies performed within this project will not only improve our understanding of this disease, but can also facilitate identification of new therapeutic targets, constituting a foundation for testing new drug classes in the treatment of periodontal disease in the future.
Key responsibilities include:
- Analyses of effects of DNMT inhibitors on gingival fibroblast (GF) and periodontal ligament fibroblast (PLF) activation, proliferation and viability in the context of P. gingivalis infection.
- Functional studies of antimicrobial responses of GFs and PLFs upon treatment with DNMT inhibitors (phagocytosis and bacterial elimination).
Profile of candidates/requirements:
- BSc degree (or equivalent) in biotechnology, biochemistry or any related field of life sciences.
- Strong experience in eukaryotic cell culture and in basic cell biology techniques (ELISA, Western Blot, qPCR) evidenced by results presented in BSc thesis or publication.
- Experience in epigenetic studies and culturing anaerobic bacteria would be an advantage.
- Fluency in written and spoken English.
- Good skills in work organization, planning and keeping experimental track record.
- High level of independence, determination and reliability, willingness to work outside of standard office hours.
- Ability to work in a team.
Required documents:
- Application/motivation letter
- CV including description of experience in laboratory work.
- Copy of a BSc degree
- A statement of knowledge and acceptance of the rules on intellectual property and legal protection of intellectual property Forms for points 3 and 5 can be downloaded from http://www.dso.uj.edu.pl/druki-do-pobrania/dokumenty-dla-kandydatow-pracownikow
- Contact information of at least one reference.
We offer:
- Participation in competitive and advanced biomedical research and MSc programme at a leading Polish university.
- Work in a well-funded research laboratory using state-of-the-art equipment and techniques.
- Collaboration with leading scientists in the field.
- Possibility to attend international scientific meetings.
Please submit the following documents to: aleksander.grabiec@uj.edu.pl (only candidates considered suitable for the post will be informed by return e-mail).
Application deadline: 19.01.2020
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