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Position of post-doc in the Department of Microbiology, FBBB JU

Rector of the Jagiellonian University announces competition for the post of ajunct proffessor (post-doc) in the department of Microbiology at the Faculty of Biochemy, Biophysics and Biotechnology

Project Description:
An estimated 850 million people worldwide is affected by chronic kidney disease (CKD) and survival of around 10 million depends on dialysis due to advanced kidney failure. Despite continuous improvement, dialysis can only replace circa 10% of physiological kidney function, leaving patients with a chronic overload of toxic metabolites. Urea is quantitatively the most abundantly retained solute in the body, where it is in equilibrium with the reactive decomposition product cyanate. Cyanate, in turn, can react with lysine residues and N-terminal amino groups of proteins and peptides, resulting in the formation of carbamyllysine (homocitrulline; HCit). This irreversible modification can occur at multiple sites within a single protein, altering protein charge, structure, and function. In the proposed project we seek to determine the impact of cyanate and carbamylation on primary hemostasis and platelet functions in CKD.
 
Key responsibilities of post-doc:
  1. Elucidate the effect of carbamylation on platelet surface proteins with special focus on GpIIb/IIIa, and how this projects on their functional integrity
  2. Characterise the carbamylation pattern of GpIIb/IIIa in vitro and in clinical samples from CKD patients
  3. Characterise the carbamylation pattern of vWF in vitro and in clinical samples from CKD patients
  4. Characterise the proteolytic cleavage of modified vWF by ADAMTS13 as well as vWF multimer distribution in patient plasma
  5. Examine the impact of vWF carbamylation on interactions with collagen, factor VIII and platelets in vitro
  6. Establish correlations between vWF carbamylation and dysfunctional vWF-protein and vWF-cell interactions in CKD
  7. Investigate the protective effect of free amino acids on carbamylation induced glycoprotein dysfunction and abnormal aggregation kinetics.
Recruitment procedure:
For the post of adjunct professor may apply persons who fulfil requirements stated in Article 113, 116 (2) (3) of the Act of 20th July 2018 Law on higher education and science, as well as in § 163 of the Statute of the Jagiellonian University, who meet the following qualification requirements:
  • Hold a PhD degree
  • Practical skills confirmed by scientific publications in biochemistry, molecular and cellular biology and proteomics (especially protein-protein interaction assays, Western blotting, flow cytometry, genetic engineering,  recombinant protein expression in bacteria and eukaryotic system, chromatographic methods, eukaryotic cell culture and identification and analysis of posttranslational modifications of proteins)
  • International research experience 
  • First authorship papers in the ISI journals
  • Excellent knowledge of English (speaking and writing)
  • Academic writing and presentation skills
  • Participation in international meetings and conferences
  • Knowledge of the commercialization of research results
  • Ability to work in an interdisciplinary team.
 
Candidates who apply for the post are required to send to the following e-mail address: piotr.mydel@uj.edu.pl the following documents:
  1. Application
  2. Curriculum vitae
  3. Copy of doctoral diploma or habilitation diploma
  4. Self-report concerning essential research areas as well as scientific achievements of a candidate
  5. List of publications (including publishing house and number of pages)
  6. Information regarding classes taught by a candidate, if applicable
  7. Opinion of the head of department or academic tutor on candidate’s suitability and qualifications for research and teaching classes – including results of students’ questionnaires, if a candidate was assessed in this manner.
Applications can be filed till: 15.01.2020.
Decision regarding competition settlement shall be made till: 31.01.2020.